Treatment with hyrdroxyurea- A case of chronic myelogenous leukemia

A physician evaluates a 32-year-old patient for fatigue. The patient is found to have an elevated white blood cell count and an enlarged spleen. A referral to an oncologist results in a diagnosis of chronic myelogenous leukemia. Treatment with hydroxyurea, a ribonucleotide reductase inhibitor is begun. The normal functioning of this enzyme is to do which of the followings ?

a) Converts xanthine to uric acid

b) Converts ribonucleotides to deoxy ribonucleotides

c) Degrades guanine to xanthine

d) Degrades AMP to IMP

e) Converts PRPP to phosphoribosylamine



Figure- Blood film of a patient suffering from Chronic myelogenous leukemia

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