Tagged: Protein aggregates

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Protein folding defect

Case details A 50-year-old male presents with “dancing –like” movements of his arms and progressive dementia. He cannot control the movement of his arms. He states that he knows that he has Huntington’s disease because his mother has the same disease. The disease is caused by abnormal protein folding. Which of the following helps to mediate proper protein folding? A. Chaperones B. Transcription factors C. DNA binding proteins D. RNA binding proteins E. All of the above.   Figure-Folding of a protein to acquire a mature functional conformation Discussion- The correct answer is Chaperones. Most proteins must fold into defined three-dimensional...

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