Tagged: point mutation

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Biochemical basis of difference in the electrophoretic mobilities of Hb A and HbS

Normal hemoglobin (Hb A) and sickle-cell hemoglobin (Hb S) have different electrophoretic mobilities because these two proteins have different what? A. Amount of bound oxygen B. Amount of bound 2, 3 bisphosphoglycerate C. Charges D. Size E. Hydrophobicity Answer- The correct answer is-C- charges. In Sickle cell disease, also called as sickle-cell anemia, a single nucleotide alteration (point mutation) in the β globin gene of hemoglobin causes a change of thymine for adenine (GAG to GTG.), at the sixth codon of the ß gene. This change encodes Valine instead of Glutamic acid in the sixth position on the ß-globin molecule....

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