Tagged: glycolysis

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Question of the day-Enzyme catalyzing Carbon-Carbon bond cleavage in Glycolysis

Which of the following enzymes cleaves a carbon-carbon bond in glycolysis? A. Phospho triose isomerase B. Aldolase C. Phospho glycerate kinase D. Enolase E. Pyruvate Kinase The correct answer is B- Aldolase. The Aldolase cleaves fructose-1,6-bisphosphate (the product of 2nd glycolytic reaction catalyzed by Phospho fructo kinase -1) between the C-3 and C-4 carbons to yield two triose phosphates. The products are dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (figure). Figure- Reactions of glycolysis. Phospho triose isomerase Of the two products of the Aldolase reaction, only glyceraldehyde-3-phosphate goes directly into the second phase of glycolysis. The other triose phosphate, dihydroxyacetone phosphate, must be...

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Fructose 2, 6 Bis phosphate and regulation of glycolysis

Case details A patient presents with dizziness, fatigue and tremors. A finger stick test indicates blood glucose of 36mmol/L. Of the allosteric activators of glycolysis in the liver, which of the following is the most important in maintaining a normal blood glucose level? A. Citrate B. ATP C. Fructose 2, 6 bisphosphate D. Glucose-6-Phosphate E. Acetyl Co A The correct answer is- C- Fructose 2,6 bisphosphate Generally, enzymes that catalyze essentially irreversible steps in metabolic pathways are potential sites for regulatory control.  Although most of the reactions of glycolysis are reversible, three are markedly exergonic and must therefore be considered...

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