Tagged: Glyceraldehyde-3-P

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Lactate to glucose conversion

Lactate is oxidized to pyruvate in a reaction catalyzed by Lactate dehydrogenase. The patients with genetic deficiency of lactate dehydrogenase present with muscle cramping and myoglobinuria after intense exercise. The sources of lactate include muscle and red blood cells. Lactate is a waste product in such cells; it is transported to liver and can be converted to glucose through pathway of gluconeogenesis. The energy requirements for conversion of lactate to glucose are: A. 2 ATP B. 4 ATP C. 6 ATP D. 8 ATP E. 38 ATP. The correct answer is C- 6 ATP. Lactate produced by active skeletal muscle...

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‘Hereditary fructose Intolerance’- Case discussion

QUESTION OF THE DAY A 3-month-old girl is brought to the pediatrician due to fussiness and lethargy. According to the parents, the baby was just fine until the mother needed to return to work, and the baby was being switched from breast milk to baby foods, formula, and fruit juices. At that time, the child cried while feeding, sometimes vomited, and had been lethargic. The baby’s appetite seemed to have worsened. The parents thought that if only formula was used, the baby was better, but they really could not remember. Which possible enzyme defect might lead to this case presentation?...

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