Tagged: Glutamine synthetase

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Case study- Hyperammonemia

Question of the day -Hyperammonemia A new-born becomes progressively lethargic after feeding. His respiratory rate increases and he becomes virtually comatose, responding only to painful stimuli, and exhibits mild respiratory alkalosis. Suspicion of a urea cycle disorder is aroused and evaluation of serum amino acid levels is initiated. In the presence of hyperammonemia, production of which of the following amino acids is always increased? A. Glycine B. Arginine C. Proline D. Histidine E. Glutamine Answer- The correct answer is Glutamine. Urea cycle disorder results in reduced ammonia disposal and hence the patients present with symptoms of hyperammonemia. Ammonia is detoxified by...

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Answer- Case study- Oral contraceptives induced vitamin deficiencies

Case Details Oral contraceptives are known to lower blood levels of folate and vitamin B6. Which of the following conversion processes might be directly affected? A. Ornithine to Citrulline B. Histidine to histamine C. Glutamate to Glutamine D. Propionyl co A to Methyl malonyl co A E. Phenyl alanine to Tyrosine Answer- B- The correct answer is conversion of Histidine to histamine. The reaction is catalyzed by decarboxylase that requires B6-P as a cofactor (Figure-1) that gets deficient in women upon long-term oral contraceptive usage. Folic acid is not required in this reaction. Figure-1- Decarboxylation of Histidine is carried out...

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