Tagged: Glutamic acid

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Biochemical basis of difference in the electrophoretic mobilities of Hb A and HbS

Normal hemoglobin (Hb A) and sickle-cell hemoglobin (Hb S) have different electrophoretic mobilities because these two proteins have different what? A. Amount of bound oxygen B. Amount of bound 2, 3 bisphosphoglycerate C. Charges D. Size E. Hydrophobicity Answer- The correct answer is-C- charges. In Sickle cell disease, also called as sickle-cell anemia, a single nucleotide alteration (point mutation) in the β globin gene of hemoglobin causes a change of thymine for adenine (GAG to GTG.), at the sixth codon of the ß gene. This change encodes Valine instead of Glutamic acid in the sixth position on the ß-globin molecule....

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Case study- Epilepsy-A 12-year-old boy develops convulsions..

Question of the day A 12-year-old boy develops convulsions. After running an electroencephalogram (EEG), a neurologist determines that the child has epilepsy. He is started on Benzodiazepine, which promotes the activity of GABA . GABA is derived from the amino acid glutamate via which of the following biochemical reactions ? A. Deamination B. Decarboxylation C. Hydroxylation D. Iodination E. Methylation Figure- Benzodiazepines  bind to the gamma sub-unit of the GABA-A receptor. Their binding causes an allosteric (structural) modification of the receptor that results in an increase in GABA A receptor activity. Benzodiazepines do not substitute for GABA, which bind at the...

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Answer- Case study- Hartnup disease- A 28- year-old man complains of a rash on his sun- exposed skin, diarrhea and loss of balance..

A 28- year-old man complains of a rash on his sun- exposed skin, diarrhea and loss of balance. His urinalysis results are significant for an increase in neutral amino acids. The patient is diagnosed with Hartnup’s disease that occurs due to a defective transport of neutral amino acids in the kidney. Apart from tryptophan which of the following amino acids would have been found in urine? A. Lysine B. Arginine C. Histidine D. Phenyl alanine E. Glutamic acid Answer The right option is D- Phenyl alanine. Hartnup disease is an autosomal recessive disorder caused by impaired neutral (i.e., mono amino...

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Case study- Hartnup’s disease- A 28- year-old man complains of a rash on his sun exposed skin, diarrhea and ..

22/01/2014 Amino acid chemistry QUESTION OF THE DAY A 28- year-old man complains of a rash on his sun exposed skin, diarrhea and loss of balance. His urinalysis results are significant for an increase in neutral amino acids. The patient is diagnosed with Hartnup’s disease that occurs due to  defective transport of neutral amino acids in the kidney. Apart from tryptophan which of the following amino acids would have been found in urine? A. Lysine B. Arginine C. Histidine D. Phenyl alanine E. Glutamic acid Figure- Patient with hartnup disease showing pellagra like rashes For answer- Follow the link http://usmle.biochemistryformedics.com/answer-case-study-hartnup-disease-a-28-year-old-man-complains-of-a-rash-on-his-sun-exposed-skin-diarrhea-and-loss-of-balance/...

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