Tagged: Biotin

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Biotin deficiency- A case report

Case details A 23-year-old body builder visits his physician with complaints of fatigue, depression, insomnia, hair loss and dry skin. He tells the physician he has been “bulking up” for an upcoming competition, and his meals consist mostly of eight raw eggs along with low-fat milk. The physician suspects biotin deficiency given the patients’ diet and symptoms. Which of the following is biotin required for? A. The formation of cis-retinal B. Transfer of 1-carbon units C. Hydroxylation reactions D. Carboxylation of pyruvate E. Decarboxylation of α-Keto acids Answer- D- Carboxylation of pyruvate is the right answer. Biotin is required for...

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Answer- Case study- Oral contraceptives induced vitamin deficiencies

Case Details Oral contraceptives are known to lower blood levels of folate and vitamin B6. Which of the following conversion processes might be directly affected? A. Ornithine to Citrulline B. Histidine to histamine C. Glutamate to Glutamine D. Propionyl co A to Methyl malonyl co A E. Phenyl alanine to Tyrosine Answer- B- The correct answer is conversion of Histidine to histamine. The reaction is catalyzed by decarboxylase that requires B6-P as a cofactor (Figure-1) that gets deficient in women upon long-term oral contraceptive usage. Folic acid is not required in this reaction. Figure-1- Decarboxylation of Histidine is carried out...

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