Tagged: AZT

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Role of “Nucleoside analogs” in HIV infection

Case details A 34-year-old homosexual man has recently been diagnosed with HIV (human immunodeficiency virus) infection. His CD4+ T-cell count has dramatically decreased, and he has a high viral load. He has been referred to an infectious disease clinic where he has been prescribed with a nucleoside analog. The nucleoside analogs inhibit DNA synthesis. Which of the following chemical groups essentially required for DNA polymerization is absent in the nucleoside analogs? A. 5′ Phosphate B. 3′ Hydroxyl C. 2′ Methyl D. 3′-Phosphate E. 5′ Hydroxyl. The correct answer is- B-3′ Hydroxyl. Basic concept Nucleosides Nucleosides are derivatives of purines and pyrimidines...

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Answer- Case study- HIV infection- A 33 -year-old, homosexual man..

Case details A 33 -year-old, homosexual man is recently diagnosed with human immuno deficiency virus (HIV) infection. His CD4+T- cell count is dramatically decreased, and he has a high HIV viral load. He is referred to an infectious disease clinic where they begin him on a nucleoside analog. These drugs inhibit DNA synthesis because they lack which of the following properties required for the normal DNA polymerization? A. 5′- phosphate B. 3′ – hydroxyl C. 7- methyl guanosine triphosphate D. Poly (A) tail E. A consensus sequence Answer- The correct option is B) – 3′-hydroxyl group .The replication proceeds with...

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