Tagged: Adenosine deaminase deficiency

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Hydroxyurea in the treatment of Leukemia

Case details A physician evaluates a 32-year-old patient for fatigue. The patient is found to have an elevated white blood cell count and an enlarged spleen. A referral to an oncologist results in a diagnosis of chronic myelogenous leukemia. Treatment with hydroxyurea, a ribonucleotide reductase inhibitor is begun. The normal functioning of this enzyme is to do which of the following? A. Converts xanthine to uric acid B. Converts ribonucleotides to deoxyribonucleotides C. Degrades guanine to xanthine D. Degrades AMP to IMP E. Converts PRPP to phosphoribosylamine   The correct answer is- B- Converts ribonucleotides to deoxyribonucleotides. Either hydroxyurea or...

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