Tagged: Acute intermittent porphria

trial 4 0

Case study- Porphyria

19/01/2014 Heme metabolism  Heme synthesis Heme biosynthesis involves eight enzymatic steps in the conversion of glycine and succinyl-CoA to heme (figure). The first and last three enzymes in the pathway are located in the mitochondrion, whereas the other four are in the cytosol. Heme is required for a variety of hemoproteins such as hemoglobin, myoglobin, respiratory cytochromes, and the cytochrome P450 enzymes (CYPs). Hemoglobin synthesis in erythroid precursor cells accounts for approximately 85% of daily heme synthesis in humans. Hepatocytes account for most of the rest, primarily for synthesis of CYPs, which are especially abundant in the liver endoplasmic reticulum,...

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