In familial hypercholesterolemia, cholesterol is deposited in various tissues because of the high concentration of LDL cholesterol in the plasma. Of particular concern is the oxidation of the excess blood LDL to form oxidized LDL (oxLDL). The oxLDL is taken up by immune-system cells called macrophages, which become engorged to form foam cells. Which statement best describes the formation of foam cells?
A. LDL receptors on peripheral cells are upregulated
B. LDL receptors for modified LDL (Ox LDL) are not down regulated
C. LDL enters by pinocytosis to form foam cells
D. There is increased de no synthesis of cholesterol
E. Cholesterol is not extracted from macrophages by HDL
Figure- Stages of Atheroma formation
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