Familial hypercholesterolemia- A case report

Case Details

In familial hypercholesterolemia, cholesterol is deposited in various tissues because of the high concentration of LDL cholesterol in the plasma. Of particular concern is the oxidation of the excess blood LDL to form oxidized LDL (oxLDL). The oxLDL is taken up by immune-system cells called macrophages, which become engorged to form foam cells. Which statement best describes the formation of foam cells?

A. LDL receptors on peripheral cells are upregulated

B. LDL receptors for modified LDL (Ox LDL) are not down regulated

C. LDL enters by pinocytosis to form foam cells

D. There is increased de no synthesis of cholesterol

E. Cholesterol is not extracted from macrophages by HDL

Foam cell formation

 

Figure- Stages of Atheroma formation

For answer, follow the link

http://usmle.biochemistryformedics.com/familial-hypercholesterolemia-case-discussion/

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7 Responses

  1. You are most welcome, sir !

  2. Thank you very much for the reference, professor Chhabra.

  3. Nature Reviews Immunology 10, 36-46 (January 2010). doi :10.1038/nri2675.

  4. Dear professor Chhabra, I would like to kindly request the reference from the picture of the stages of atheroma formation.

    Thanks a lot fot your attention.

  5. Thank you madam.. I make it a point to try to answer your questions.. All the best:-)

  6. Perfect answer, Shabneez, well done !

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