Category: Hemoglobinopathies

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A microcytic anemia and elevated iron levels in tissues

An 8-year-old child has been brought to his pediatrician by his parents after they noticed that he felt very fatigued. They also noted that his abdomen seemed to be enlarged. Examination reveals an enlarged spleen. Further history reveals that the child been given vitamins and iron supplements over the last few months. Laboratory tests show a microcytic anemia and elevated iron levels in tissues. Which of the following conditions is most consistent with the findings in this patient? A. Aplastic anemia B. Sickle cell anemia C. Pernicious anemia D. Thalassemia major E. Thalassemia minor The correct answer is E- Thalassemia...

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Biochemical basis of difference in the electrophoretic mobilities of Hb A and HbS

Normal hemoglobin (Hb A) and sickle-cell hemoglobin (Hb S) have different electrophoretic mobilities because these two proteins have different what? A. Amount of bound oxygen B. Amount of bound 2, 3 bisphosphoglycerate C. Charges D. Size E. Hydrophobicity Answer- The correct answer is-C- charges. In Sickle cell disease, also called as sickle-cell anemia, a single nucleotide alteration (point mutation) in the β globin gene of hemoglobin causes a change of thymine for adenine (GAG to GTG.), at the sixth codon of the ß gene. This change encodes Valine instead of Glutamic acid in the sixth position on the ß-globin molecule....

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