Category: Biological Oxidation and ETC

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Case study- Mutation in complex II of ETC

An -8 year-old boy is seen by an ophthalmologist for difficulties in seeing in all visual fields as well as slow eye movements. The ophthalmologist finds pigmentary retinopathy and ophthalmoplegia. The child is suspected to have Kearns- Sayre syndrome, a disorder due to a mutation in complex II of ETC. The electron transport from which substance would be impaired? A. Malate B. Isocitrate C. Succinate D. Pyruvate E. Alpha Keto glutarate Answer- The correct answer is C- Succinate. Electrons flow through the respiratory chain through a redox span of 1.1 V from NAD+/NADH to O2/2H2O passing through three large protein...

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Case study Malignant hyperthermia (Electron transport chain and oxidative phosphorylation)

Case details A 23-year-old college foot ball player sustains a compound fracture on the field. He is taken to surgery, during which the anesthesiologist notes a significantly increased body temperature (102 0 F). The operation is terminated without completion, as malignant hyperthermia is suspected. Which of the following components of ETC is likely to be responsible for this phenomenon? A. Complex I B. Complex II C. Complex III D. Complex IV E.  ATP synthase complex Answer- The right answer is- E- ATP Synthase complex. Patients with malignant hyperthermia experience uncoupling of oxidative phosphorylation . OXIDATIVE PHOSPHORYLATION Chemiosmosis- As the electrons...

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Case study- Malignant hyperthermia (Electron transport chain and oxidative phosphorylation)

Basic concept Electron Transport Chain The electron transport chain (ETC) is a series of membrane-bound electron carriers (Figure-1) Embedded in the mitochondrial inner membrane Electrons from NADH and FADH2 are transferred to complexes of the ETC Each complex transfers the electrons to the next complex in the chain. COMPLEXES OF ELECTRON TRANSPORT CHAIN Electrons flow through the respiratory chain through a redox span of 1.1 V from NAD+/NADH to O2/2H2O passing through three large protein complexes; NADH-Q oxidoreductase (Complex I), where electrons are transferred from NADH to coenzyme Q (Q) (also called ubiquinone); Q-cytochrome c oxidoreductase (Complex III), which passes...

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