Category: Biochemistry of HIV Infection

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Role of “Nucleoside analogs” in HIV infection

Case details A 34-year-old homosexual man has recently been diagnosed with HIV (human immunodeficiency virus) infection. His CD4+ T-cell count has dramatically decreased, and he has a high viral load. He has been referred to an infectious disease clinic where he has been prescribed with a nucleoside analog. The nucleoside analogs inhibit DNA synthesis. Which of the following chemical groups essentially required for DNA polymerization is absent in the nucleoside analogs? A. 5′ Phosphate B. 3′ Hydroxyl C. 2′ Methyl D. 3′-Phosphate E. 5′ Hydroxyl. The correct answer is- B-3′ Hydroxyl. Basic concept Nucleosides Nucleosides are derivatives of purines and pyrimidines...

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Case study- HIV infection

Case details A 25-year-old female is sexually active with a new partner and would like to have an HIV test. The current standard for HIV testing is to start with an enzyme- linked immuno sorbent assay (ELISA). HIV antigens are coated on a plate, and the patient’s serum is added. If the patient has HIV antibodies, binding of these antibodies to the antigens on the plate will be detected. If the ELISA test is positive, a confirmatory test is done. In this confirmatory test, the patient’s serum is added to HIV antigens, which are on a nitrocellulose membrane. This confirmatory...

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