Category: Biochemistry of cancer

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Methotrexate in rheumatoid arthritis

Case details A 63- year-old woman presents with a long history of joint pains. Physical examination reveals severely deformed fingers secondary to rheumatoid arthritis. The rheumatologist recommends Methotrexate. This drug inhibits which of the following conversions? A. Dopamine to norepinephrine B. Tyrosine to Dopa C. Folate to dihydrofolate D. Histidine to formiminoglutamate (FIGLU) E. Norepinephrine to Vanillylmandelic acid The correct answer is- C. Folate to dihydrofolate conversion. The reaction is catalyzed by dihydrofolate reductase; the same enzyme catalyzes the conversion of Dihydrofolate to tetrahydrofolate. The enzyme is competitively inhibited by Methotrexate, which is also used as an anticancer drug. It...

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Answer- Case study- Breast lump

A 23-year-old woman is seen for a lump in her breast that she palpated on self breast examination. History reveals that her mother and her aunt both had breast and ovarian cancer. Given this presentation, it is suspected that the patient might be having a mutation in which of the following genes involved in DNA repair? A. BRCA-1 B. p53 C. Rb D. p10 E. ras Answer- The correct answer is- A. BRCA- 1 gene is implicated in breast and ovarian cancer. A major cause of familial breast cancer results from mutation in the breast cancer susceptibility gene, BRCA1. BRCA1...

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Case study- Breast lump

Question of the day A 23-year-old woman is seen for a lump in her breast that she palpated on self breast examination. History reveals that her mother and her aunt both had breast and ovarian cancer. Given this presentation, it is suspected that the patient might be having a mutation in which of the following genes involved in DNA repair? A. BRCA-1 B. p53 C. Rb D. p10 E. ras   Figure- Breast lump For answer, follow the link http://usmle.biochemistryformedics.com/answer-case-study-breast-lump/   Please help Biochemistry for Medics by “CLICKING ON THE ADVERTISEMENTS” every time you visit us. Thank you!

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