Question of the day
A 12-year-old boy develops convulsions. After running an electroencephalogram (EEG), a neurologist determines that the child has epilepsy. He is started on Benzodiazepine, which promotes the activity of GABA . GABA is derived from the amino acid glutamate via which of the following biochemical reactions ?
Figure- Benzodiazepines bind to the gamma sub-unit of the GABA-A receptor. Their binding causes an allosteric (structural) modification of the receptor that results in an increase in GABA A receptor activity. Benzodiazepines do not substitute for GABA, which bind at the alpha sub-unit, but increase the frequency of channel opening events which leads to an increase in chloride ion conductance and inhibition of the action potential.
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